More Possible Uses:
Boost Calcium Absorption
BOOST CALCIUM ABSORPTION: A benign method to address the problem of calcium absorption would be beneficial for those in need of long term treatment. Dr. Fusao Tomita has done extensive work on calcium absorption. He has shown that rats fed certain difructose anhydrides, including one made utilizing levan, absorb significantly more calcium than control animals (Saito a). It was suggested these compounds have potential in preventing osteoporosis (Saito b). We are now searching for funding to continue this promising work.
Mineo H, Hara H, Kikuchi H, Sakurai H, Tomita F. Various indigestible saccharides enhance net calcium transport from the epithelium of the small and large intestine of rats in vitro. The Journal of Nutrition 131: 3243-3246 (2001).
Mineo H, Hara H, Shigematsu N, Okuhara Y, Tomita F. Melibiose, difructose anhydride III and difructose anhydride IV enhance net calcium absorption in rat small and large intestinal epithelium by increasing the passage of tight junctions in vitro. The Journal of Nutrition 132: 3394-3399 (2002).
Saito K, Tomita F. Difructose anhydrides: their mass-production and physiological functions. Bioscience, Biotechnology and Biochemistry 64: 1321-1327 (2000). (a)
Saito K, Kondo K, Kojima I, Yokota A, Tomita F. Purification and characterization of 2,6-β-D-fructan 6-levanbiohydrolase from Streptomyces exfoliatus F3-2. Applied and Environmental Microbiology 66: 252-256 (2000). (b)